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Keep track of Closely (one)pentobarbital will lessen the extent or effect of fentanyl by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep an eye on Intently. Coadministration of fentanyl with CYP3A4 inducers could lead on to your decrease in fentanyl plasma concentrations, not enough efficacy or, maybe, progress of the wit